proposed amendment to the food and drug regulations project no. 1596 schedule f 4 pages available in english and french this notification announces the availability of a letter that provides an opportunity to comment on the proposed addition of three medicinal ingredients to part i of schedule f to the food and drug regulations. description of the medicinal ingredients 1. imidapril and its salts and derivatives is an angiotensin converting enzyme ace inhibitor that is used to treat high blood pressure in dogs. practitioner expertise is required to diagnose the specific condition causing high blood pressure. the condition may require additional treatment with other prescription drugs and routine laboratory monitoring. imidapril and its salts and derivatives possesses the potential for undesirable side effects at normal therapeutic doses. 2. tepoxalin and its derivatives is a nonsteroidal anti-inflammatory drug nsaid that is used to control pain and inflammation associated with musculoskeletal disorders in dogs. tepoxalin and its derivatives has the potential for undesirable side effects at normal therapeutic doses. there is a narrow margin of safety between the therapeutic and toxic dosages in older dogs. 3. tulathromycin is a macrolide antibiotic that is used to treat lung infections such as pneumonia in cattle and pigs. direct practitioner supervision and monitoring are required for diagnosis and for the safe use of this product. tulathromycin may contribute to the development of resistant strains of micro-organisms. the degree of regulatory control afforded by schedule f prescription drug status coincides with the risk factors associated with each medicinal ingredient. oversight by a practitioner is necessary to ensure that appropriate risk benefit information is considered before the drug containing the medicinal ingredient is administered and that the drug therapy is properly monitored. schedule f is a list of medicinal ingredients the sale of which is controlled under sections c.01.041 to c.01.049 of the food and drug regulations. part i of schedule f lists ingredients that require a prescription for human use and for veterinary use. part ii of schedule f lists ingredients that require a prescription for human use but do not require a prescription for veterinary use if so labelled or if in a form unsuitable for human use.