interim marketing authorization regarding the use of the pullulanase enzyme available in english and french pages 3995-3996 provision currently exists in the food and drug regulations for the use of the enzyme pullulanase at levels consistent with good manufacturing practice in the production of starch-derived sweetening agents and a variety of bakery products. the permitted sources of this enzyme are the microorganisms bacillus acidopullulyticus ncib 11647 and bacillus licheniformis se2-pul-int211 pubcdebra11dnsi . health canada has received a submission to permit the use of the pullulanase enzyme obtained from a genetically modified bacillus subtilis organism bacillus subtilis rb121 pdg268 that carries the gene from bacillus deramificans coding for this enzyme. evaluation of available data supports the safety and effectiveness of this pullulanase obtained from the genetically modified bacillus subtilis rb121 pdg268 . the use of this pullulanase enzyme will benefit both the consumer and industry through the increased availability of quality food products and more efficient and improved manufacturing conditions. therefore it is the intention of health canada to recommend that the food and drug regulations be amended to permit the use of the pullulanase enzyme obtained from the genetically modified bacillus subtilis rb121 pdg268 in the production of distillers mash and brewers mash and of dextrins maltose dextrose glucose glucose syrup or glucose solids dried glucose syrup at levels consistent with good manufacturing practice. as a means to improve the responsiveness of the regulatory system an interim marketing authorization ima is being issued to permit the immediate use of this pullulanase enzyme as indicated above while the regulatory process is undertaken to formally amend the regulations. a revision to this notification will be published at the start of the amendment process and members will be given the opportunity at that time to submit comments on this proposed measure