interim marketing authorization regarding the use of the phospholipase a2 enzyme in the production of bread flour whole wheat flour unstandardized bakery products unstandardized whole egg unstandardized egg yolk and modified lecithin health canada has received a submission to permit the use of the phospholipase a2 enzyme derived from a genetically modified aspergillus niger strain aspergillus niger pla-54 that carries the gene from another strain of aspergillus niger coding for this enzyme. phospholipase enzymes are classified under the broad class of lipase enzymes. this phospholipase a2 enzyme will be used in the production of bread flour whole wheat flour unstandardized bakery products unstandardized whole egg unstandardized egg yolk and modified lecithin at levels consistent with good manufacturing practice. evaluation of the available data supports the safety and effectiveness of this phospholipase a2 derived from the genetically modified aspergillus niger pla-54 . therefore it is the intention of health canada to recommend that the food and drug regulations be amended to permit the use of this phospholipase a2 enzyme derived from aspergillus niger pla-54 in the production of bread flour whole wheat flour unstandardized bakery products unstandardized whole egg unstandardized egg yolk and modified lecithin at levels consistent with good manufacturing practice. as a means to improve the responsiveness of the regulatory system an interim marketing authorization is being issued to permit the immediate use of this phospholipase a2 enzyme as indicated above while the regulatory process is undertaken to amend the regulations. the proposed regulatory amendments would be enabling measures to allow the sale of the foods mentioned above that have been manufactured through the use of the phospholipase a2 enzyme derived from aspergillus niger pla-54 . the amendments are supported by the safety assessment and would have low impact on the economy and on the environment. consequently the regulatory amendments may proceed directly to final approval and publication in the canada gazette part ii