notice dichlorvos ddvp proposed determination to terminate special review this notice sets forth epas proposed determination to terminate special review for the pesticide dichlorvos ddvp . on 24 february 1988 the agency published a notice of special review pd 1 of pesticide products containing ddvp based on concerns for cancer cholinesterase inhibition and liver effects. on 28 september 1995 the agency published a notice of preliminary determination to cancel certain registrations and a draft notice of intent to cancel pd 2 3 . in the 1995 pd 2 3 the agency determined that exposure to dichlorvos from the registered uses posed carcinogenic risks of concern as well as risks of concern for cholinesterase inhibition. however with respect to liver effects the agency determined that this endpoint was no longer of regulatory concern. since the initiation of special review and publication of the pd 2 3 additional data have become available. based in part on these data the agency has changed its assessment of some of the risks associated with ddvp and modified the terms and conditions of ddvp registrations accordingly. moreover during the recently-concluded reregistration process for ddvp epa conducted an intensive and public review of whether ddvp registrations meet the fifra standard for registration culminating in the agencys 2006 interim reregistration eligibility decision ired for ddvp. through the reregistration processes the agency resolved remaining concerns regarding cancer and cholinesterase effects. accordingly epa has revised its assessment of ddvp since the time when the pd 1 and the pd 2 3 were published. based on the ired requested label amendments and the voluntary cancellation of uses by the registrant pursuant to federal law epa has determined that the risks that were the basis of the special review are no longer of concern and therefore the agency is proposing to terminate the special review of ddvp. to the extent that the agency further revises its assessment of ddvp it will do so outside of the special review context.