regulation of the director general of indonesian national agency for drug and food control nadfc no. 10 of 2016 concerning the uses of enzyme and enzyme immobilization agents categorized as processing aids on food processing based on law number 18 2012 regarding food food is any edible matter derived from organic sources in plantation farming forestry fishery animal husbandry waters and water processed or unprocessed for the purpose of food or beverage for human consumption including food additives food ingredients and other ingredients used for preparation processing and or production of food and drink. other ingredients including uses of processing aids. the requirements use of enzyme as processing aids and enzyme immobilization agents on food processing are not yet regulated. this regulation is intended to be used as reference for the registration certification and controller and supervision and anticipation to prevent abuse. the regulation covers enzyme and or enzyme immobilization agents as processing aids are deliberating. this regulation developed version from another country about processing aids and this regulation has a positive list for category enzyme with maximum residual is gmp and can used for all processing food. for the category enzyme immobilization agent have a maximum residual. the principles of processing aids usage a. must be used as low as possible to achieve the desirable effect and b. must be attempted followed by residual removal and or inactivation at the end of food processing. the residual removal and or inactivation of enzyme may be done as follows a. heating b. ph modification with allowable acidity regulator substance which followed by filtration and centrifugation c. suitable molecular filtration for enzyme and or d. other relevant method the residual removal for enzyme immobilization agent may be done as follows a. filtration b. removal immobilization agent c. centrifugation and or d. other relevant method the usage of genetically modified processing aids should meet the related regulations