proposed amendment to the food and drug regulations project no. 1621 schedule f 4 pages available in english and french this notification announces the availability of a letter that provides an opportunity to comment on the proposed addition of four medicinal ingredients to part i of schedule f to the food and drug regulations. description of the medicinal ingredients 1. dirlotapide is a microsomal triglyceride transfer protein inhibitor that is used to treat obesity in dogs. direct supervision by a practitioner and routine laboratory monitoring are required. dirlotapide has the potential for undesirable side effects at normal therapeutic doses. 2. firocoxib is a cox-2 cyclooxygenase inhibitor type of nonsteroidal anti-inflammatory drug nsaid that is used to control pain and inflammation associated with osteoarthritis in dogs. firocoxib has the potential for undesirable side effects at normal therapeutic doses. there is a narrow margin of safety between the therapeutic and toxic dosages in younger and older dogs. 3. ibafloxacin is a fluoroquinolone antibiotic that is used to treat bacterial infections in dogs and cats. ibafloxacin has the potential for undesirable side effects at normal therapeutic doses. a practitioner must provide individualized instructions and supervision. ibafloxacin may contribute to the development of resistant strains of micro-organisms. 4. maripotant and its salts is a selective neurokinin one nk1 receptor antagonist that is used to treat and prevent acute vomiting in dogs. individualized instructions direct practitioner supervision and routine laboratory monitoring are required. maripotant and its salts is used in serious disease states and its use may mask other ailments. the degree of regulatory control afforded by schedule f prescription drug status coincides with the risk factors associated with each medicinal ingredient. oversight by a practitioner is necessary to ensure that appropriate risk benefit information is considered before the drug containing the medicinal ingredient is administered and that the drug therapy is properly monitored. schedule f is a list of medicinal ingredients the sale of which is controlled under sections c.01.041 to c.01.049 of the food and drug regulations. part i of schedule f lists ingredients that require a prescription for human use and for veterinary use. part ii of schedule f lists ingredients that require a prescription for human use but do not require a prescription for veterinary use if so labelled or if in a form unsuitable for human use.